Epigenetic regulation of endometrium during the menstrual cycle
نویسندگان
چکیده
منابع مشابه
O-31: Epigenetic Aberration of HOXA10 Gene in Human Endometrium throughout The Menstrual Cycle in Endometriosis
Background: Epigenetic aberration such as DNA methylation and histone modifications appear to be involved in various diseases such as Endometriosis. Here, we investigated the epigenetic regulation of HOXA10 promoter, as a crucial gene, responsible for uterine organogenesis, functional endometrial differentiation and endometrial receptivity, and its correlation with mRNA expression of this gene ...
متن کاملP-217: Expression Analysis of The Histone Variant H2A.Z in Endometrium Tissue during The Menstrual Cycle
Background: The human endometrium undergoes cyclical changes including proliferation, differentiation, tissue breakdown and shedding (menstruation) throughout a woman’s reproductive life. The postovulatory rise in ovarian progestrone induces profound remodeling in chromatin structure of cells, and consequently differentiation of estradiol-primed endometrium. This change is crucial for embryo im...
متن کاملThioredoxin expression in the human endometrium during the menstrual cycle.
Human thioredoxin, a cellular disulphide reducing protein, is known to be secreted by some types of cells and to display unique extracellular activities including modulation of cytokine actions and protection of the cell against damage from oxidative stress. This study has been undertaken to investigate the pattern of expression and tissue distribution of thioredoxin in human endometrium during...
متن کاملRegulation of sulphotransferase expression in the endometrium during the menstrual cycle, by oral contraceptives and during early pregnancy.
The endometrium plays a key role in reproduction, and this function is tightly regulated by endogenous and xenobiotic steroids. Sulphation, catalysed by members of the sulphotransferase (SULT) enzyme family, is a major deactivating mechanism for steroid hormones and we have investigated the expression and regulation in vivo of SULT in the human endometrium. In the normal cycling endometrium, ex...
متن کاملexpression patterns of vegf and flk-1 in human endometrium during the menstrual cycle
background: the vegf is essential in the process of tissue remodeling and angiogenesis. limited data is available on the expression and regulation of vegf and its receptors in the human endometrium. the aim of this study was evaluation of expression patterns of vegf and flk-1 in human endometrium during the menstrual cycle. methods: sixty paraffin-embedded blocks of endometrial tissues from the...
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ژورنال
عنوان ژورنال: Molecular Human Reproduction
سال: 2010
ISSN: 1360-9947,1460-2407
DOI: 10.1093/molehr/gaq010